Clinical care guidelines (CCGs) were first implemented at the Ann & Robert H. Lurie Children’s Hospital of Chicago in October 2019. CCGs were intended to standardize post-operative management by removing unnecessary variations in clinical care that were believed to increase patient length of stay (LOS). Initially, these CCGs were surgery-specific; however, in November of 2020 they were modified to an aspirational post-operative LOS. Our straightforward ventricular septal defect (VSD) patients now use the 2-day LOS CCG. We report early results for VSD patients after CCG implementation.